Posted: September 8th, 2011 | Author: admin | Filed under: Side Effects | Tags: acute renal failure, antifungals, atorvastatin, biosynthesis of cholesterol, cholesterol level, coronary heart disease, cyclosporine, cytochrome p 450, hmg coa reductase inhibitors, lovastatin, lowering cholesterol, metabolic pathway, myocardial infarction, myopathies, pain and suffering, rare problems, reducing cholesterol, reported side effects, rhabdomyolysis, simvastatin | No Comments »
Simvastatin is a member of the hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or also called as statins.
Simvastatin or statin are used in the treatment of dyslipidemia.
The marketing for Simvastatins or statins are approved by the FDA way back in 1991.
These drugs reduce the biosynthesis of cholesterol by inhibiting the the early and rate-limiting step in the conversion of HMG-CoA to mevalonate.
Statins are regarded as the most suitable and effective medications for lowering cholesterol.
Simvastatin or statins are also associated with a reduced risk of mortality and nonfatal myocardial infarction for those with coronary heart disease.
There are also a serious but rare problems with statins that is rhabdomyolysis with or without acute renal failure.
For most cases, rhabdomyolysis or other types of myopathies have been the knowned caused by drug interactions, specifically with drugs that inhibit the cytochrome P-450 (CYP) 3A4 metabolic pathway (e.g., macrolides, certain antifungals, and cyclosporine). Simvastatin, atorvastatin, and lovastatin are most sensitive to these interactions.
Patients taking Simvastatin react differently from each other due to the differences in dosage for each patient also because of body reactions to the treatment.
Although Simvastatin have been regarded as the most powerful medication for the treatment of reducing cholesterol level in patients , there are still side effects for those that are using this medication.
There are people who experienced the side effects and there are people who don’t experience any side effects.
Is is well to note that Simvastatin side effect is tolerated by most patients.
Three of the most reported side effects of Simvastatin are feeling week (asthenia),having abdominal pain and suffering from headaches.
The statistics in percentage for the above are headaches ( 3.5 percent ), abdominal pain ( 3.2 percent ) and feeling weak ( 1.6 percent ).
Other side effects that are noted are:
- Muscle pain ( myalgia ).
- Upper respiratory infections.
All of the above are general side effects that users may experience for taking other types of medication for a series of particular disease.
For example if you experience headaches, you can take analgesic to ease the pain. A proper diet can also remedy the side effects.
Studies are done for the side effects of Simvastatin and about 1% of them are found to have side effects.
The side effects that are found are:
- Muscle cramps.
- Muslcle aches.
- Joint Pain.
- Memory loss.
- Allergic reactions.
- Gynecomastia or breast development in boys.
- Worsening of cataracts.
- Itchy and dry skin.
- Unexplained rashes.
- Increased liver enzymes.
- Vertigo ( spinning sensation ).
Those who experienced any type of allergic reactions, itchiness or rash may be allergic to one of the components of Simvastatin.
If you experience one of the above symptoms after taking Simvastatin, you need to stop taking the medication and consult your doctor or physician immediately. Your doctor or physician may prescribe another medication for you.
There are also cases where extra dosage are taken by patients which in turn will create the side effects of Simvastatin above.
You and your doctor or physician need to discuss of any possible side effects and the proper dosage for Simvastatin before you start taking them.
Posted: June 8th, 2011 | Author: admin | Filed under: Side Effects | Tags: bile secretion, blood stream, blood vessel problems, cholestatic hepatitis, cholesterol level, cholesterol production, cirrhosis of the liver, excess cholesterol, heart attacks, hypercholesterolemia, muscle cramps, muscle damage, muscle disease, muscle fibers, muscle pains, muscle proteins, myopathy, rhabdomyolysis, simvastatin, simvastatin side effects | No Comments »
If you are considering taking Simvastatin then you need to make sure you know the details of Simvastatin side effects.
Simvastatin is used to reduced the cholesterol level for those that have excessive cholesterol. Simvastatin is a drug from the statin family.
It is also used for children to treat a condition known as heterozygous hypercholesterolemia. Heterozygous hypercholesterolemia is a condition where the body failed to remove excess cholesterol properly.
Simvastatin works by slowing down the cholesterol production in the body. Simvastatin can also be used to reduce the risks of heart attacks, strokes, blood flow issues that are related to heart and blood vessel problems.
It is used in doses from 5mg to 80mg.There are many side effects for Simvastatin.Each one having its own symptoms.
Simvastatin can cause an increased risk of muscle damage resulting from muscle disease called myopathy that will cause a non functioning of the muscle fibers.
This will happen when a patient takes higher doses of Simvastatin. The symptoms for this includes weakness, tenderness, spasms, stiffness and muscle cramps.
More serious side effects of using Simvastatin is the chance to develop rhabdomyolysis.
Rhabdomyolysis is a condition where muscle proteins are released directly into the blood stream. This can leads to fatal kidney or damaged kidney.
This problem can happen if you use Simvastatin with other medication which will produce conflicts or increased absorption of Simvastatin into the blood stream.
The symptoms for this conflicts includes stiffness, weakness, muscle pains and dark colored urine.
A symptom called the cholestatic hepatitis can also happen. This means there is an obstruction of bile secretion which will cause bile to re enter the blood stream.
Symptoms for this includes jaundice and itching of the skin. This condition can lead to hepatic necrosis.
Another problem that may arise is called Hepatic Cirrhosis ( cirrhosis of the liver ).
This will cause a degeneration of the liver cells which are then replaced by scar tissues.
This can leads to serious liver damage and can be fatal.
Symptoms for those who suffers from Hepatic Cirrhosis includes a tendency to bruise easily, itching, jaundice, loss of appetite and fatigue ( tiredness ).
Other common symptoms that are reported includes memory loss, joint pain, diarrhea, headaches, nausea, stomach pain and constipation.
If you are taking Simvastatin and you have the above symptoms then it is best to consult your doctor or physician immediately.
There is no serious damage to those who take Simvastatin.
The best thing to do is take precaution measures when taking Simvastatin.
Do not mix Simvastatin with other medication before informing your doctor or physician first.
You need to inform your doctor or physician if you use a medication and need to take Simvastatin after that so they can determine if both medication can be mix together or not.
A few medication that you need to watch out if you want to mix them are antifungal medications, other type of cholesterol drugs and also anticoagulants.
Even if you take harmless medication and use them with Simvastatin then you must make sure your doctor or physician monitors the interactions between those two.
Another thing to monitor is doing a regular liver checkups when you start using Simvastatin. There are a variety of liver problems that can happen to those who take Simvastatin so it is important for you to do a regular checkup to look for any changes to your body.
Posted: January 8th, 2011 | Author: admin | Filed under: Side Effects | Tags: bile secretion, cholesterol ldl, dark urine, flow problem, heart attacks, hepatic cirrhosis, hypercholesterolemia, liver cells, liver damage, loss of appetite, muscle cramps, muscle fibers, muscle problems, muscle proteins, myopathy, reducing bad cholesterol, rhabdomyolysis, simvastatin, simvastatin side effects, stomach pain | No Comments »
Simvastatin is regarded as cholesterol handling drug or medication.
Simvastatin came from the statin family. It is helpful in reducing bad cholesterol ( LDL) in adults and Heterozygous hypercholesterolemia.
Heterozygous hypercholesterolemia is a condition where the body fails to discharge cholesterol accurately in young people. The doctor or physician will prescribes the drug in the doses of 5mg to 8mg.This will decelerate the bad cholesterol ( LDL) production and this will reduce the blood flow problem, rate of strokes and heart attacks.
There are many types of Simvastatin and every single one has its own signs and symptoms.
One of the side effects is damage to the muscle as a consequence of a muscle illness known as Myopathy which will result in lifeless muscle fibers.
For those that take higher doses of Simvastatin , they are more prone for the situation whose symptoms are stiffness, tenderness, muscle cramps, spasms and weakness.
Another side effects that is witnessed is called holestatic hepatitis which refers to a group of bile secretion where the organ re-enter into the blood stream.
If this happen, you will suffer from jaundice or skin itching
If this conditions are not treated properly, the conditions will turn into hepatic nerosis.
Another critical side effects of Simvastatin is rhabdomyolysis. Rhabdomyolysis will release the muscle proteins directly into the blood immediately. This will result in damaged kidneys and this will make the organ failed to function or function properly.
There will also be side effects if you blend Simvastatin with other medications or drugs.
If you do this most probably you will suffer from dark urine,stiffness and muscle problems.
The most critical of Simvastatin side effects will be cirrhosis of the liver or hepatic cirrhosis.
This is the symptoms of liver cells reduction and a very serious liver damage.
The symptoms for this condition would be stomach pain, bruising, fatique, loss of appetite, itching and jaundice.
If you consume alcohol, an elderly above 65 years or an Asian, you can suffer more from Simvastatin side effects.
People with thyroid problem, diabetes and even pregnant or breast-feeding mother are best to avoid taking this medication.
Below are the most common side effects associated with Simvastatin:
- Memory loss.
- Stomach pain.
- Joint pain.
Although the above are not serious issues to dealt with , you still need to inform your doctor or physician if you get one while taking Simvastatin.
The good news is there are no serious or rare damage to your body although there are still side effects from using Simvastatin.
If you want to avoid the risks of these side effects then your doctor or physician can help you to recognize the complete lists of side effects from using Simvastatin.
At last , don’t take Simvastatin if you are taking other drugs or medications without informing your doctor or physician first. You also need to tell which medication you are currently taking to your doctor for confirmation. Your doctor or physician can tell you if you can mix both medications together.
The most sensitive drugs to be mix together are anticoagulants including other cholesterol controlling medications and antifungal drugs.
You also need to go to liver checkup regularly because the side effects of Simvastatin to the liver.